The Sierra de Perijá white-fronted capuchin, like all capuchins, is generally diurnal (active during the day) and primarily arboreal (tree-dwelling). They are likely most commonly seen early in the morning when they can be found foraging for food in the middle canopy of the forest or on the forest floor.

Very few studies have been conducted specifically on the Sierra de Perijá white-fronted capuchin. This includes specifics regarding their behavior and lifestyle. If we look at other species of white-fronted capuchins, it can be presumed that much of the day is spent foraging for food in groups, while nights are spent sleeping upon the branches of the trees. Like other capuchins, the primary mode of locomotion is quadrupedalism, that is, moving on four limbs, though they may also be capable of standing and walking upright.

Besides humans, predators that target the Sierra de Perijá white-fronted capuchin have not been documented. Looking at other capuchin species, however, they face threats from jaguars, cougars, coyotes, tayras, snakes, crocodiles, and birds of prey. While studies of this capuchin species are again, lacking, it can be assumed that, like other capuchins, they utilize an array of defense techniques to avoid predation. These may include emitting alarm calls which may vary depending upon the type of predator, remaining vigilant while foraging by staying close together in groups, spending most of their time in the trees to avoid ground-based predators, using their natural agility to beat a hasty retreat, using their natural coloration to act as camouflage which allows them to blend in with their tree-based habitat, and selecting habitats that offer better protection from predators, such as dense forests, with plenty of cover and escape routes.